Mfg Part Number
QBD-10011-1000
Vector Labs QBD-10011-1000 Phthalimidooxy-dPEG®₄-NHS ester - 1000 mg (1/EA)
Quick Overview
Tris (2-carboxyethyl) phosphine hydrochloride (TCEP)
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Phthalimidooxy-dPEG®4-NHS ester, product number QBD-10011, is a protected aminooxy compound linked to an amine-reactive N-hydroxysuccinimidyl (NHS) ester through a single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This allows a hydrophilic, protected aminooxy group to be installed on peptides, proteins, small molecules, and amine-functionalized surfaces.
The amine-reactive NHS ester has optimal reactivity in the pH range of 7.0 – 7.4. This group should be reacted first as the subsequent deprotection step for the aminooxy group will also react with the NHS ester.
The phthaloyl moiety on phthalimidooxy-dPEG®4-NHS ester stably protects the aminooxy group. Following amide bond formation, the phthalimide group can be removed using aqueous hydrazine or hydroxylamine, leaving the aminooxy group free to react.
Oxime bonds form from the reaction between an aminooxy group and an aldehyde or ketone. If the formative reaction is between an aminooxy and an aldehyde, the oxime bond formed is called an aldoxime. The oxime bond formed by the reaction of an aminooxy and a ketone is called a ketoxime. Compared to hydrazone bonds, oxime bonds are exceptionally stable. They do not break under physiological or even slightly acidic conditions that can occur under some physiological states.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |