Mfg Part Number
QBD-10217-1000
Vector Labs QBD-10217-1000 MPS (NHS-3-maleimidopropionate) - 1000 mg (1/EA)
Quick Overview
MPS (NHS-3-maleimidopropionate) - 250 mg
$238.58
Order will ship within 1-3 business days
MPS (NHS-3-maleimidopropionate), product number QBD-10217, is the N-hydroxysuccinimidyl (NHS) ester of 3-(maleimido)propanoic acid and is used to crosslink sulfhydryls with amines. This product does not contain a dPEG® spacer between the reactive groups. The distance is six atoms (6.0 Å) from the reactive site of the maleimide to the carbonyl carbon of the propanoic acid.
The maleimido group reacts with sulfhydryl groups to form thiol ether bonds. In the range of pH 6.5 – 7.5, the thiol-maleimide reaction is chemoselective. Above pH 7.5, the maleimide group can also react with free amine groups. Consequently, high pH buffers should be avoided when using this product.
NHS esters are widely popular for reactions of carboxylic acids with primary or secondary amines to form stable amide bonds. Although the NHS ester hydrolyzes rather easily in water or aqueous buffer, this product can be dissolved in a water-miscible solvent such as N,N’-dimethylacetamide (DMAC) that has been dried over 3 Å molecular sieves. The solution of MPS is then added to the water or aqueous buffer to start the reaction.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |