Mfg Part Number
QBD-10311-1000
Vector Labs QBD-10311-1000 Amino-dPEG®₂₄-t-butyl ester - 1000 mg (1/EA)
Quick Overview
Fmoc-N-amido-dPEG₂₄-acid - 100 mg
$1,077.27
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Amino-dPEG®24–t-butyl ester, product number QBD-10311, is a heterobifunctional, monodisperse polyethylene glycol (PEG) linker containing a single molecular weight and discrete length PEG (dPEG®) chain. One end of the dPEG® chain terminates with a carbonyl-reactive primary amine. The opposite end terminates with an amine-reactive, tert-butyl-ester-protected propionic acid. The t-butyl ester protecting group cleaves easily with trifluoroacetic acid (TFA), exposing a propionic acid moiety that forms amide bonds with primary amines upon activation. This compound is useful for supramolecular construction and building novel crosslinkers. Conjugates modified with QBD-10311 have improved water solubility and greater hydrodynamic volume.
The amine end of the molecule reacts with activated carboxylic acid esters (for example, N-hydroxysuccinimidyl or tetrafluorophenyl esters) to form an amide bond. Also, carboxylic acids can couple to the amine end of Amino-dPEG®24-t-butyl ester using a carbodiimide such as EDC, with or without an acylating agent such as N-hydroxysuccinimide (NHS).
After working up the reaction to remove unreacted components and isolate the intermediate, trifluoroacetic acid is used to remove the tert-butyl ester and expose the propionic acid end group. The exposed carboxylic acid can then react further. For example, activation as the NHS or TFP ester is possible. Also, the acid can be coupled directly to an amine as described above.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |