Mfg Part Number
QBD-10319-1000
Vector Labs QBD-10319-1000 m-dPEG®₂₄-MAL - 1000 mg (1/EA)
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MPS-Acid - 100 mg
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m-dPEG®24-MAL, product number QBD-10319, is a sulfhydryl-reactive, single molecular weight, with a discrete chain length PEG (dPEG®). This product modifies surfaces and biomolecules with free thiol groups through the maleimide reactive group. The non-immunogenic, methyl-terminated dPEG® chain has no charge but adds water solubility and hydrodynamic volume to molecules to which it is conjugated.
The reaction of the maleimide end of m-dPEG®24-MAL, product number QBD-10319, with a sulfhydryl proceeds best at pH 6.5 – 7.5. Conduct the conjugation at the lowest reasonable pH within this range. Above pH 7.5, free amines compete with free thiols at the maleimide reaction site, which creates confusing results. Moreover, at higher pH values, the maleimide ring may open to form unreactive maleamic acid.
Published uses for m-dPEG®24-MAL include the following:
modifying surface-accessible free thiols on enzymes to probe enzymatic function;
developing a virus-based drug delivery system; and,
developing probes of cellular redox reactions.
Published uses for m-dPEG®24-MAL include the following:
modifying surface-accessible free thiols on enzymes to probe enzymatic function;
developing a virus-based drug delivery system; and,
developing probes of cellular redox reactions.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |