Mfg Part Number
QBD-11435-25
Vector Labs QBD-11435-25 Tetra(-amido-dPEG®₁₁-MAL)pentaerythritol - 25 mg (1/EA)
Quick Overview
Amino-dPEG₁₂-Tris(-dPEG₂₄-t-butyl ester)₃ - 100 mg
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Tetra(-amido-dPEG®11-MAL)pentaerythritol, product number QBD-11435, is a maleimide-functionalized PEG crosslinking reagent designed to join up to four molecules via a maleimide-thiol reaction. Each of the four arms of this product comes from a single molecular weight, discrete polyethylene glycol (dPEG®) spacer that is 43 atoms (47.4 Å) long, joined through a pentaerythritol core. Product applications include (1) crosslinking of proteins, peptides, or small molecules containing free sulfhydryl groups and (2) dendrimer construction with thiol-functionalized branched compounds.
The thiol-maleimide reaction, also known as the thiol-Michael addition, is a click chemistry reaction. This powerful, highly popular reaction is extensively used in bioconjugation applications. At pH 6.5 – 7.5, the thiol-maleimide reaction is chemoselective. However, above pH 7.5, the maleimide group reacts competitively with amines, so the pH should be kept below this limit.
Unlike traditional polyethylene glycol (PEG), which are non-uniform, dispersed polymers, Vector Laboratories’ dPEG® products are single molecular weight PEGs with discrete chain lengths, hence the dPEG® name.
Tetra(-amido-dPEG®11-MAL)pentaerythritol showcases one of the benefits of dPEG® linkers in product development. Each of the four dPEG® arms is identical, and the uniformity simplifies analysis. In contrast, if this product were made using traditional, non-uniform PEG compounds, analyzing it would be much more complicated and challenging.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 25 mg |