Mfg Part Number
QBD-10041-100
Vector Labs QBD-10041-100 Amino-dPEG®₄-t-boc-hydrazide - 100 mg (1/EA)
Quick Overview
Amino-dPEG₄-t-boc-hydrazide
$183.33
Order will ship within 1-3 business days
Amino-dPEG®4-t-boc hydrazide, product number QBD-10041, is a useful molecular modification and bioconjugation reagent. The product has a free, primary amine on one end of a short (18 atoms, 21.1 Å) single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) linker. The other end of this linker has a boc-protected hydrazide group. The free amine reacts with carboxylic acids and their active esters to form a stable amide bond. Following the removal of the Boc protecting group, the hydrazide can be reacted with an aldehyde (for example, formed from periodate oxidation of carbohydrates) at pH 5 – 7 to form a hydrazone bond. Hydrazone bonds are acid labile but otherwise stable, thus allowing the conjugate or supramolecular construct to degrade under acidic conditions such as in lysosomes or the acidic extracellular microenvironments at inflammation or tumor metastasis sites. The single molecular weight, discrete PEG (dPEG®) crossbridge is water-soluble and non-immunogenic, and it adds flexibility and increases the hydrodynamic volume of conjugates and supramolecular constructs that incorporate it.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |