Mfg Part Number
QBD-11580-250
Vector Labs QBD-11580-250 MAL-dPEG®₄-Glu(OH)-NH-m-dPEG®₂₄ - 250 mg (1/EA)
Quick Overview
MAL-dPEG₄-Glu(OH)-NH-m-dPEG₂₄
$1,108.21
Order will ship within 1-3 business days
MAL-dPEG®4-Glu(OH)-NH-m-dPEG®24, product number QBD-11580, is one of Vector Laboratories’ unique, patented class of modular, designable payload delivery reagents called Sidewinder™. Sidewinder™ products are built on a discrete PEG (dPEG®) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain’s sidearm. The distal end’s methoxy-terminated dPEG®24 spacer protects payloads and modifies performance.
The maleimide reactive group of MAL-dPEG®4-Glu(OH)-NH-m-dPEG®24, product number QBD-11580, reacts with free thiols on the biomolecule through the thiol-maleimide reaction (a Michael addition reaction) to form a stable thioether bond. The sidearm is an amine-reactive carboxylic acid. It can be reacted directly with free amines to form stable amide bonds using a carbodiimide like EDC. Alternatively, the carboxylic acid can be functionalized as the active ester with N-hydroxysuccinimide (NHS ester) or 2,3,5,6-tetrafluorophenol (TFP ester) and then reacted with free amines.
Sidewinder™ products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload (e.g., a cytotoxin) close to the antibody surface and protecting it with a SuperHydrophilic™ dPEG® construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity.
The dPEG® linkers and spacers in the Sidewinder™ construct are uniform, single molecular-weight PEGs with discrete chain lengths. In contrast, traditional, non-uniform polymer PEG linkers and spacers have a dispersed range of PEG chain lengths, each with a unique molecular weight. Unlike dispersed polymer PEGs, dPEG® products are high-purity compounds with reproducible purity profiles.
Sidewinder™ molecules are also fully designable. MAL-dPEG®4-Glu(OH)-NH-m-dPEG®24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with other reactivities, change the maleimide attachment group to another reactive group, and many more customizations. Please inquire about your specific needs.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 250 mg |