Mfg Part Number
QBD-11624-250
Vector Labs QBD-11624-250 NH₂-dPEG®₄-Glu(OH)-NH-dPEG®₄-Glu(OH)-NH-m-dPEG®₂₄ - 250 mg (1/EA)
Quick Overview
NH₂-dPEG₄-Glu(OH)-NH-dPEG₄-Glu(OH)-NH-m-dPEG₂₄
$1,026.44
Order will ship within 1-3 business days
NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24, product number QBD-11624, is one of Vector Laboratories’ unique, patented class of modular, designable payload delivery reagents called Sidewinder™. Sidewinder™ products are built on a discrete PEG (dPEG®) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain’s sidearm. The distal end’s methoxy-terminated dPEG®24 spacer protects payloads and modifies performance.
The free primary amine of NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24, product number QBD-11624, reacts with carboxylic acids or their active esters (NHS ester, TFP ester) to form stable amide bonds. It is the attachment point for the Sidewinder™ to the biomolecule (e.g., mAb, Fab, Fab’, targeting peptide, and so forth). The amine can be modified with a reactive group or conjugated directly to the carrier molecule. The backbone contains two carboxylic acid sidearms. After the primary amine is reacted, functionalized, or protected, the two sidearms can be conjugated to amine-containing payloads. The conjugation can be direct, using EDC or another suitable carbodiimide, or indirect, after first functionalizing the acid groups with N-hydroxysuccinimide (NHS ester) or 2,3,5,6-tetrafluorophenol (TFP ester) and then reacting the active esters with the amine-containing payloads.
Sidewinder™ products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload close to the antibody surface and protecting it with a SuperHydrophilic™ dPEG® construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity.
The dPEG® linkers and spacers in the Sidewinder™ construct are uniform, single molecular-weight PEGs with discrete chain lengths. In contrast, traditional, non-uniform polymer PEG linkers and spacers have a dispersed range of PEG chain lengths, each with a unique molecular weight. Unlike dispersed polymer PEGs, dPEG® products are high-purity compounds with reproducible purity profiles.
Sidewinder™ molecules are also fully designable. NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with other reactivities, change the amine attachment group to another reactive group, and many more customizations. Please inquire about your specific needs.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 250 mg |