Mfg Part Number
QBD-10149-100
Vector Labs QBD-10149-100 m-dPEG®₁₂-amido-dPEG®₁₂-TFP ester - 100 mg (1/EA)
Quick Overview
m-dPEG₁₂-amido-dPEG₁₂-TFP ester
$333.61
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m-dPEG®12-amido-dPEG®12-TFP ester, product number QBD-10149, is a long (77 atoms, 91.3 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. The reactive end of the molecule is a 2,3,5,6-tetrafluorophenyl (TFP) ester. An amide bond joining two discrete PEG subunits is in the molecule’s center. m-dPEG®12-amido-dPEG®12-TFP ester is designed to modify surfaces containing accessible free amines. Applications for m-dPEG®12-amido-dPEG®12-TFP ester include cell surface engineering, improving PK/BD, reducing bioconjugate immunogenicity, preventing protein aggregation, constructing dendrimers, and many more.
m-dPEG®12-amido-dPEG®12-TFP ester reacts with amine-functionalized surfaces (carbon nanotubes, nanoparticles made of silica or various metals, quantum dots, and similar types of products) or free amines on biomolecules. When used to coat surfaces or modify biomolecules, m-dPEG®12-amido-dPEG®12-TFP ester reduces or eliminates non-specific binding and increases water solubility. Crucially, the elimination of non-specific binding may increase the signal-to-noise ratio in imaging applications and assays where this is a consideration. Please note that modifying the surface amines of biomolecules with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates. When reacting TFP esters with free amines, the optimal pH range is 7.5 – 8.5.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |