Mfg Part Number
QBD-10160-100
Vector Labs QBD-10160-100 S-acetyl-dPEG®₈-OH - 100 mg (1/EA)
Quick Overview
S-acetyl-dPEG₈-OH
$183.33
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S-acetyl-dPEG®8-OH, product number QBD-10160, contains an acetyl-protected thiol on a hydroxy-terminated, discrete polyethylene glycol (dPEG®) linker. This product thiolates biomolecules.
Bioconjugation frequently employs thiolation because the reactions to install thiol groups on molecules or to react with molecules containing sulfhydryl groups are relatively simple and often chemoselective. The thioacetyl group is intended to install an acetyl-protected thiol onto biomolecules. While installing a protected thiol through a reaction between a carboxylic acid and a primary amine is widely popular in bioconjugation technology, it is not always possible or feasible. S-acetyl-dPEG®8-OH permits the installation of a protected thiol through a short, hydroxy-terminated discrete PEG® linker. Hydroxylamine hydrochloride (CAS number 5470-11-1) easily removes the S-acetyl group that protects the thiol, thus exposing the sulfhydryl for subsequent reaction. One application for S-acetyl-dPEG®8-OH is the modification of nucleic acids using phosphoramidite chemistry.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |