Mfg Part Number
QBD-10247-100
Vector Labs QBD-10247-100 Thiol-dPEG®₄-acid - 100 mg (1/EA)
Quick Overview
Thiol-dPEG₄-acid
$243.00
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Thiol-dPEG®4-acid, product number QBD-10247, contains a short, monodisperse polyethylene glycol (PEG) linker functionalized with a sulfhydryl group on one end and a propionic acid moiety on the other.The sulfhydryl forms dative bonds with gold and silver and reacts with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.
Thiol-dPEG®4-acid forms dative bonds with gold surfaces and provides a non-immunogenic, hydrophilic spacer between the gold coat and the environment surrounding the gold. The terminal carboxylic acid can be left unmodified, or it can react with amines to crosslink other molecules to the gold.
In published scientific literature, Thiol-dPEG®4-acid in a mixed monolayer has prevented opsonization of gold nanoparticles. Other published uses for this product include coating nanoparticles, coating gold electrodes used in ion channel recording, developing aptamer-based sensors, and developing a chemical detector with nanometer-scale spatial resolution.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |