Mfg Part Number
QBD-10262-1000
Vector Labs QBD-10262-1000 m-dPEG®₁₂-NHS ester - 1000 mg (1/EA)
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Amino-dPEG₂-t-butyl ester - 100 mg
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m-dPEG®12-NHS ester, product number QBD-10262, is a medium-length (38 atoms, 44.7 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with an N-hydroxysuccinimidyl (NHS) ester for reaction with amines.
NHS esters react optimally with free amines at pH 7.0 – 7.5. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.
Many applications employ this m-dPEG®12-NHS ester. Published papers using this product include uses in:
vaccine development;
cell surface engineering;
multimodal imaging;
stable antimicrobial, cytotoxic dendrimers;
nanoparticles for siRNA delivery;
coating of nanoparticles, quantum dots, and carbon nanotubes;
PK and immunogenicity improvements for organophosphorus hydrolase;
PK and immunogenicity improvements for poly-L-lysine dendrimers used as drug delivery vehicles to tumors; and,
preventing enzyme aggregation.
m-dPEG®12-NHS ester, product number QBD-10262, is just one member of a comprehensive line of methyl-terminated dPEG® products, including dPEG® spacers containing 2 to 49 ethylene glycol units.
vaccine development;
cell surface engineering;
multimodal imaging;
stable antimicrobial, cytotoxic dendrimers;
nanoparticles for siRNA delivery;
coating of nanoparticles, quantum dots, and carbon nanotubes;
PK and immunogenicity improvements for organophosphorus hydrolase;
PK and immunogenicity improvements for poly-L-lysine dendrimers used as drug delivery vehicles to tumors; and,
preventing enzyme aggregation.
m-dPEG®12-NHS ester, product number QBD-10262, is just one member of a comprehensive line of methyl-terminated dPEG® products, including dPEG® spacers containing 2 to 49 ethylene glycol units.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |