Mfg Part Number
QBD-10266-1000
Vector Labs QBD-10266-1000 MAL-dPEG®₂-NHS ester - 1000 mg (1/EA)
Quick Overview
CBZ-N-amido-dPEG₄-acid - 100 mg
$272.83
Order will ship within 1-3 business days
MAL-dPEG®2-NHS ester, product number QBD-10266, is a thiol-reactive and amine-reactive crosslinking reagent that joins a sulfhydryl to a free amine. The sulfhydryl groups react with a maleimide group via a Michael addition reaction. The amines form amide bonds with the crosslinker by nucleophilic substitution of the N-hydroxysuccinimidyl (NHS) ester of a carboxylic acid group. The maleimide and NHS functional groups on the crosslinking compound sit at either end of a short, discrete-length polyethylene glycol chain (dPEG®).
The reaction of the maleimide end of MAL-dPEG®2-NHS ester proceeds optimally at pH 7.0 – 7.5, though it can go as low as pH 6.5. Use the lowest reasonable pH within this range. Above pH 7.5, free amines compete with free thiols at the maleimide reaction site, causing confusing results. Moreover, at higher pH values, the maleimide ring may open to form unreactive maleamic acid.
The use of MAL-dPEG®2-NHS ester has been published in many different scientific papers and patents. The following list highlights some of the more notable uses of this product:
Cell targeting;
Crosslinking peptides to passivated nanoparticle surfaces;
Stem cell membrane engineering;
Biosensor development;
Cell capture using aptamers;
Controlled, targeted delivery of siRNA;
Development of extracellular antibody-drug conjugates; and,
Development of multiplex assays.
Cell targeting;
Crosslinking peptides to passivated nanoparticle surfaces;
Stem cell membrane engineering;
Biosensor development;
Cell capture using aptamers;
Controlled, targeted delivery of siRNA;
Development of extracellular antibody-drug conjugates; and,
Development of multiplex assays.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |