Mfg Part Number
QBD-10303-100
Vector Labs QBD-10303-100 m-dPEG®₂₄-TFP ester - 100 mg (1/EA)
Quick Overview
m-dPEG₂₄-TFP ester
$287.20
Order will ship within 1-3 business days
m-dPEG®24-TFP ester, product number QBD-10303, is a long (74 atoms, 86.2 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-dPEG®24-TFP ester is designed to modify surfaces having accessible free amines.
Free amines react optimally with TFP esters in aqueous media at pH 7.5 – 8.0. TFP esters are more hydrolytically stable in water and aqueous buffers than NHS esters. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH increases. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.
Many applications could potentially use m-dPEG®24-TFP ester successfully. Among those applications are:
cell surface engineering;
PK, BD, and immunogenicity profile improvements for biomolecules;
imaging applications by reducing background and non-specific binding;
dendrimer construction;
nanoparticle, quantum dot, and carbon nanotube surface coating; and,
prevention of protein aggregation.
cell surface engineering;
PK, BD, and immunogenicity profile improvements for biomolecules;
imaging applications by reducing background and non-specific binding;
dendrimer construction;
nanoparticle, quantum dot, and carbon nanotube surface coating; and,
prevention of protein aggregation.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |