Mfg Part Number
QBD-10342-1000
Vector Labs QBD-10342-1000 Amino-dPEG®₁₂-ODMT - 1000 mg (1/EA)
Quick Overview
DNP-dPEG₄-acid - 100 mg
$1,088.32
Order will ship within 1-3 business days
Amino-dPEG®12-ODMT, product number QBD-10342, is designed for nucleic acid modification in applications where PEGylation improves the therapeutic or diagnostic profile. It contains a medium-length (38 atoms), single molecular weight, discrete PEG (dPEG®) linker with a free primary amine on one end and dimethoxytrityl-protected oxygen on the other. Following oligonucleotide synthesis, amino-dPEG®12-ODMT can be conjugated to phosphate groups on either end of the chain using water-soluble 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry. The 4,4′-dimethoxytrityl group can then be removed using a weak acid, such as dilute dichloroacetic acid, leaving the dPEG® linker terminated with a hydroxy group. Studies have shown that 3′ end capping (including PEGylation) helps the oligonucleotide chain resist nuclease degradation, while 5′ end PEGylation reduces renal clearance of the aptamer.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |