Mfg Part Number
QBD-10397-50
Vector Labs QBD-10397-50 Bis-MAL-dPEG®₁₁ - 50 mg (1/EA)
Quick Overview
DNP-dPEG₁₂-acid - 100 mg
$272.83
Order will ship within 1-3 business days
Bis-MAL-dPEG®11, product number 10397, is a medium-length, homobifunctional, crosslinking reagent that links two molecules (e.g., peptides, proteins) together via the thiol-maleimide reaction (also known as the thiol-Michael addition). The ends of the molecule are both functionalized with maleimidopropionate groups. The two reactive ends are separated by a single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The thiol-maleimide reaction, a type of click chemistry reaction, is an extremely popular way to conjugate molecules. The maleimide functional group rapidly reacts with sulfhydryl groups, and the reaction is chemoselective for sulfhydryls in the pH range of 6.5 – 7.5. The polyethylene glycol (PEG) spacer between the two maleimide groups is a single molecular weight compound with a discrete chain length (thus the tradename dPEG®). This product is not made from a disperse polymer but is instead a single compound. Applications for this product include, among many others, studying cell internalization of crosslinked proteins; developing FRET immunoassays; and anchoring biomolecules to surfaces.
If you publish research with this product, please let us know so we can cite your paper.
Interleukin-2 (IL-2) is a powerful growth factor in a variety of cell types and plays key roles in T cell differentiation and function, B cell development, and NK cell activation. This cytokine is part of the body's natural response to microbial infection, and in distinguishing between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes. It has been shown to be involved in itchy psoriasis.
From the laboratory of United States Department of Agriculture/USDA
C22H26N2O3
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 50 mg |