Mfg Part Number
QBD-10401-1000
Vector Labs QBD-10401-1000 NHS-dPEG®₄-(m-dPEG®₁₂)₃-ester - 1000 mg (1/EA)
Quick Overview
MAL-dPEG₄-(m-dPEG₁₂)₃ - 100 mg
$1,570.10
Order will ship within 1-3 business days
NHS-dPEG®4-(m-dPEG®12)3 ester, product number QBD-10401, is a water-soluble, amine-reactive, single molecular weight, branched PEGylation reagent built around a tris core and used to modify amine-functionalized surfaces and biomolecules. Three equal-length dPEG®12 branches terminate with methyl groups. A short dPEG®4 arm ends with an amine-reactive N-hydroxysuccinimidyl (NHS) ester. From the terminal carbonyl carbon of the dPEG®4 arm to each terminal methyl group on the dPEG®12 branches, the distance is 66 atoms (51.1 Å) long. This hydrophilic branched dPEG® product adds hydrodynamic volume to the conjugates, which reduces immunogenicity and renal clearance. Moreover, this product reduces or eliminates non-specific binding to conjugates and surfaces.
The reaction chemistry for coupling a free amine to an NHS ester is standard in almost all bioconjugation labs worldwide. Numerous scientific publications attest to the benefits of NHS-dPEG®4-(m-dPEG®12)3 ester. These reports describe this product being used to:
Coat nanoparticle surfaces;
Create imaging applications;
Develop Antibody-Drug Conjugates (ADCs);
Modify PK and BD of biomolecular conjugates;
Prevent non-specific binding;
Passivate inorganic surfaces such as metal and diamond; and,
Develop hemerythrin-based blood substitutes.
Coat nanoparticle surfaces;
Create imaging applications;
Develop Antibody-Drug Conjugates (ADCs);
Modify PK and BD of biomolecular conjugates;
Prevent non-specific binding;
Passivate inorganic surfaces such as metal and diamond; and,
Develop hemerythrin-based blood substitutes.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |