Mfg Part Number
QBD-11385-5
Vector Labs QBD-11385-5 Carboxyfluorescein-dPEG®₂₄-amido-dPEG®₂₄-DSPE - 5 mg (1/EA)
Quick Overview
Biotin-dPEG₄-amido-dPEG₂₄-amido-dPEG₂₄-DSPE
$634.17
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Carboxyfluorescein-dPEG®24-amido-dPEG®24-DSPE, product number QBD-11385, consists of the lipid 1,2-Distearoyl-SN-glycero-3-phosphoethanolamine (DSPE) conjugated to a long (152 atoms, 180.0 Å), single molecular weight, discrete polyethylene glycol (dPEG®) spacer that has been functionalized with 5(6)-carboxyfluorescein. The dPEG® spacer consists of two dPEG®24 linkers joined by an amide bond, making the spacer effectively a dPEG®48 product with a molecular weight of slightly more than 2,000 Daltons (i.e., equivalent to a PEG2000). The product is designed for use in liposomes and micelles where a fluorescent dye label is needed. The carboxyfluorescein dye has an absorbance maximum (λex) of 497 nm and an emission maximum (λem) of 524 nm, with an extinction coefficient of 63303 M-1 cm-1 at 497 nm, and an A280 correction factor of 0.18.
Liposomes and micelles are often coated with traditional, polymeric PEG2000 (a polymer PEG having an average molecular weight of 2,000 Daltons) at a density of about 5 – 8 mole%. A polymer PEG2000 consists of an intractable mixture of different chain lengths and molecular weights of PEG, making analysis difficult. Unlike a traditional, non-uniform (that is, dispersed) PEG2000, QBD-11385, carboxyfluorescein-dPEG®24-amido-dPEG®24-DSPE is a single, uniform product. Carboxyfluorescein-dPEG®24-amido-dPEG®24-DSPE is designed to provide a convenient dye label for liposomes, micelles, and other lipid nanoparticles. This allows labeled liposomes and micelles to be tracked over time.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 5 mg |