Quick Overview
Conjugation: CF405S Genus/Species: Mus musculus (mouse), Bos taurus (bovine)
Details
GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Additional Information
| Brand | Biotium |
|---|---|
| UNSPSC | 41116161 |
| Size | 500 uL |
| Clonality | N/A |
| Concentration | No |
| Features | N/A |
| Target | N/A |
| Reactivity Species | N/A |
| Host | N/A |
| Conjugation | CF405S |
| Antibody Line | N/A |
| Antibody Type | N/A |
