Mfg Part Number
BNC740976-500
Biotium GITR / Tnfrsf18 (Mouse)(DTA-1), CF740 conjugate, 0.1mg/mL, 500 uL, 1 Each
Quick Overview
Conjugation: CF740 Genus/Species: Mus musculus (mouse), Bos taurus (bovine) Size: 500 uL, 1 Each
$784.00
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GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
| Brand | Biotium |
|---|---|
| UNSPSC | 41116161 |
| Size | 500 uL |
| Clonality | Monoclonal |