Mfg Part Number
BNC741786-500
Biotium p63 (Squamous, Basal and Myoepithelial Cell Marker) (TP63/1786), CF740 conjugate, 0.1mg/mL, 500 uL, 1 Each
Quick Overview
Conjugation: CF740 Genus/Species: Mus musculus (mouse), Bos taurus (bovine) Size: 500 uL, 1 Each
$784.00
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p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80%. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.
Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
| Brand | Biotium |
|---|---|
| UNSPSC | 41116161 |
| Size | 500 uL |
| Clonality | Monoclonal |
| Host | Mouse |
| Antibody Type | Primary Antibody |