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Biotium BNC881592-100, Aurora B (Proliferation Marker)(AURKB/1592), CF488A conjugate, 0.1mg/mL

Vendor: Biotium

Mfg Part Number: BNC881592-100

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Quick Overview

Conjugation: CF488A Genus/Species: Mus musculus (mouse), Bos taurus (bovine)
Price: $204.80

Ships in 1-3 days if in stock. Contact us for current availability.

Quick Overview

Conjugation: CF488A Genus/Species: Mus musculus (mouse), Bos taurus (bovine)

Details

This antibody recognizes a protein of 39 kDa, which is identified as Aurora kinase B (or Aurora B). Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Additional Information

Brand Biotium
UNSPSC 41116161
Size 100 uL
Clonality N/A
Concentration No
Features N/A
Target N/A
Reactivity Species N/A
Host N/A
Conjugation CF488A
Antibody Line N/A
Antibody Type N/A

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