Enzo ALX-380-313-M001 Atpenin A5 (synthetic) (1 mg)

3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone

White to off-white powder.

119509-24-9

Mitochondrial complex

Inhibitor

C₁₅H₂₁Cl₂NO₅

366.2

≥95% (HPLC)

CJ8800000

Soluble in acetone, acetonitrile, chloroform, ethyl acetate, DMSO, methanol or 100% ethanol; insoluble in water or hexane.

Synthetic. Originally isolated from Penicillium sp. strain FO-125.

The IC₅₀ value against bovine heart complex II is 3.6nM (which is ~300-fold lower than the IC₅₀ value of carboxin (1.1μM)). It also inhibits fumarate reductase of Ascaris suum (IC₅₀ = 12nM). Inhibition of E. coli succinate dehydrogenase is less potent (IC₅₀ = 5μM).By co-crystallization studies of atpenin A5 and complex II, the binding site of atpenin A5 was found to be the quinone-binding site of complex II. Additionally, atpenin A5 has been shown to have a protective action against ischemia-reperfusion via the activation of mitochondrial K_ATP channels.

As indicated on product label or CoA when stored as recommended.

-20°C

Ambient Temperature