Enzo ALX-522-021-C010 TWEAK (soluble) (human), (recombinant) (10 µg)

Apo-3L, TNFSF 12

ELISA: binds to FN14 receptor at 10-100 ng/ml.

Kills TWEAK sensitive cells.

0.1mg/ml after reconstitution.

<0.1EU/µg purified protein (LAL test; Bio Whittaker).

Lyophilized. Contains PBS.

~18-20kDa (SDS-PAGE).

≥90% (SDS-PAGE)

Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.

Produced in E. coli. The extracellular domain of human TWEAK (aa 106-249) is fused at the N-terminus to a linker peptide (11 aa) and a FLAG^®-tag.

Binds to human and mouse Fn14 (TWEAK-R).

Historical data has shown that TWEAK has a pro-apoptotic effect on several target cell lines, and it induces angiogenesis and proliferation in endothelial cells.

FLAG is a registered trademark of Sigma-Aldrich Co.

O43508

Stable for at least 6 months after receipt when stored at -20°C.

Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

-20°C

Blue Ice