Mfg Part Number
QBD-10166-100
Vector Labs QBD-10166-100 Methoxytrityl-S-dPEG®₈-acid - 100 mg (1/EA)
Quick Overview
Methoxytrityl-S-dPEG₈-acid
$243.00
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Methoxytrityl-S-dPEG®8-acid, product number QBD-10166, permits the introduction of a protected thiol-dPEG® spacer/linker onto a molecule by reaction with a free amine. The methoxytrityl (Mmt) protected thiol deprotects under relatively mild conditions using dilute trifluoroacetic acid (TFA) with a scavenger.
QBD-10166 permits our customers to insert a short (28 atoms, 32.5Å) dPEG® into a peptide chain using familiar solid phase or solution phase chemistry. The dPEG® can be inserted at the N-terminus of a peptide chain or on any amino acid side chain with an exposed free amine. In addition, the short dPEG® spacer can be used simply to provide additional distance in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® means that the construct will gain some degree of water solubility while remaining soluble in organic solvent. The Mmt protecting group removes relatively easily with a dilute solution of TFA that also contains a scavenger such as triethylsilane (TES) or triisopropylsilane (TIPS). Once the thiol group is deprotected, it can be reacted with another thiol to form a disulfide bond or with any thiol-reactive group such as maleimide, bromoacetamide, alkene (thiol-ene reaction) or alkyne (thiol-yne reaction).
Upon activation, Methoxytrityl-S-dPEG®8-acid reacts with any free amine, whether on a peptide, surface, or other molecule. This allows for a broad range of applications where this product can be employed to convert an amine to a thiol.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |