Mfg Part Number
QBD-10288-1000
Vector Labs QBD-10288-1000 m-dPEG®₁₂-amine - 1000 mg (1/EA)
Quick Overview
m-dPEG₁₂-MAL - 100 mg
$544.66
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m-dPEG®12-amine, product number QBD-10288, is a non-immunogenic, water-soluble chemical modification reagent. The product contains a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain terminated on one end with a methyl group and on the other end with a reactive primary amine. The amino group reacts with carboxylic acids (and their active esters), aldehydes, and ketones. Reacting the amino group with aldehydes or ketones forms a labile imine (Schiff base). Reacting carboxylic acids or their active esters with m-dPEG®12-amine forms stable amide bonds. Uses for this product include passivating surfaces and coating biomolecules.
Biomolecules modified with m-dPEG®12-amine display enhanced water solubility, increased hydrodynamic volume, and reduced immunogenicity. This product reacts quickly with active esters of carboxylic acids (for example, NHS esters and TFP esters) to form amide bonds. Also, it forms amide bonds directly with carboxylic acids using the carbodiimide EDC.
Several publications in the scientific literature report the successful use of m-dPEG®12-amine. Published reports using this product include:
cancer imaging with a NIR-fluorescent peptosome;
multimodal imaging and targeted gene silencing;
noncompetitive on-chip immunoassays;
antibody pretargeting; and,
the development of biocompatible quantum dots.
cancer imaging with a NIR-fluorescent peptosome;
multimodal imaging and targeted gene silencing;
noncompetitive on-chip immunoassays;
antibody pretargeting; and,
the development of biocompatible quantum dots.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |