Mfg Part Number
QBD-10306-1000
Vector Labs QBD-10306-1000 m-dPEG®₁₂-TFP ester - 1000 mg (1/EA)
Quick Overview
Biotin-dPEG₃-TFPA
$725.88
Order will ship within 1-3 business days
m-dPEG®12-TFP ester, product number QBD-10306, is a medium-length (38 atoms, 44.0 Å), methyl-terminated, discrete-length polyethylene glycol (dPEG®) spacer. With a reactive end of 2,3,5,6-tetrafluorophenyl (TFP) ester, m-dPEG®12-TFP ester is designed to modify surfaces having accessible free amines.
Free amines react optimally with TFP esters in aqueous media at pH 7.5 – 8.0. TFP esters are more hydrolytically stable in water and aqueous buffers than NHS esters. Nevertheless, in aqueous media, the rate at which the ester hydrolyzes to the carboxylic acid increases as the pH increases. Moreover, it should be noted that reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.
There are numerous applications that could successfully employ m-dPEG®12-TFP ester, including the following:
vaccine development;
cell surface engineering;
imaging applications to reduce background and non-specific interactions;
construction of dendrimers;
coating of nanoparticles, quantum dots, and carbon nanotubes;
improving PK and BD of biomolecules; and,
preventing enzyme aggregation.
vaccine development;
cell surface engineering;
imaging applications to reduce background and non-specific interactions;
construction of dendrimers;
coating of nanoparticles, quantum dots, and carbon nanotubes;
improving PK and BD of biomolecules; and,
preventing enzyme aggregation.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |