Mfg Part Number
QBD-10378-1000
Vector Labs QBD-10378-1000 SPDP-dPEG®₁₂-NHS ester - 1000 mg (1/EA)
Quick Overview
SPDP-dPEG₂₄-NHS ester - 100 mg
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SPDP-dPEG®12-NHS ester, product number QBD-10378, is a medium-length (44 atoms), hydrophilic, non-immunogenic, heterobifunctional crosslinker that has the same functionality as the widely popular, but unfortunately hydrophobic, SPDP crosslinker. It contains an amine-reactive N-hydroxysuccinimidyl (NHS) ester on one end of the dPEG®12 linker and a thiol-reactive SPDP (also known as OPSS) reactive group on the other end. The longer spacer arm may facilitate the reaction of the SPDP end of the molecule with buried thiol groups.
Among the most popular heterobifunctional crosslinking reagents used in bioconjugate chemistry are those compounds that conjugate molecules containing free amine groups with molecules that contain sulfhydryl groups. SPDP (N-succinimidyl 3-(2-pyridyldithio)-propionate) is one of the most popular versions of this type of crosslinker. Unfortunately, SPDP and its popular varieties (LC-SPDP and Sulfo-LC-SPDP) are hydrophobic molecules. When conjugated to biomolecules, care must be taken not to modify the target molecules too much, because this can precipitate the conjugate products.
By contrast, SPDP-dPEG®12-NHS ester, product number QBD-10378, is used like SPDP and its related hydrophobic products. However, precautions against overly modifying the target molecule are not necessary. The water-soluble dPEG® product will not cause the resulting conjugates to precipitate due to excessive hydrophobicity.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |