Mfg Part Number
QBD-10501-100
Vector Labs QBD-10501-100 Azido-dPEG®₄-NHS ester - 100 mg (1/EA)
Quick Overview
Azido-dPEG₄-NHS ester
$268.41
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Azido-dPEG®4-NHS ester, product number QBD-10501, contains an azide group linked to an N-hydroxysuccinimidyl (NHS) ester through a single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This product works with copper(I)-catalyzed, ruthenium-catalyzed click chemistry, and copper-free (e.g., strain-promoted) click chemistry. The dPEG® spacer imparts water solubility and adds hydrodynamic volume to the conjugated product. The single molecular weight product design, with its discrete chain length, simplifies analysis of this product.
NHS esters are the most popular, most widely used way to conjugate carboxylic acids to primary or secondary amines resulting in stable amide bonds. NHS esters react quickly and efficiently in aqueous media at physiological pH values (7.0 – 7.5). However, they are prone to hydrolysis over time. Moreover, the rate of hydrolysis is pH dependent. Consequently, they must be used immediately upon dissolution in water or aqueous buffer. Published research has shown that 2,3,5,6-tetrafluorophenyl (TFP) esters are more hydrolytically stable and have better reactivity with amines than NHS esters.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |