Mfg Part Number
QBD-10513-1000
Vector Labs QBD-10513-1000 Azido-dPEG®₁₂-acid - 1000 mg (1/EA)
Quick Overview
Azido-dPEG₂₄-acid - 100 mg
$876.16
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Azido-dPEG®12-acid, product number QBD-10513, is a click chemistry crosslinking reagent functionalized with an azide group and a propionic acid group on opposite ends of a linear spacer. A water-soluble, medium-length (40 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) spacer separates the two groups. The azide moiety reacts in copper(I)-catalyzed, ruthenium-catalyzed, and strain promoted azide-alkyne cycloadditions (CuAAC, RuAAC, and SPAAC, respectively). Alternatively, the azide functions as a masked amine. In this role, the carboxylic acid end of the molecule must couple with an amine to form an amide bond. The azide group is then reduced to a primary amine to permit crosslinking with a carboxylic acid group. The propionic acid moiety can be coupled to a primary or secondary amine by an acylation reaction.
The carboxylic acid group of Azido-dPEG®12-acid can be coupled directly to a free amine using EDC or some other carbodiimide. Also, forming the active ester of the acid using N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) before reacting with free amines is a useful course of action.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |