Mfg Part Number
QBD-10571-100
Vector Labs QBD-10571-100 Azido-dPEG®₂₄-TFP ester - 100 mg (1/EA)
Quick Overview
Azido-dPEG₂₄-TFP ester
$350.18
Order will ship within 1-3 business days
Azido-dPEG®24-TFP ester, product number QBD-10571, is a crosslinking compound designed for copper(I)-catalyzed, ruthenium catalyzed, and strain promoted click chemistry (CuAAC, RuAAC, and SPAAC, respectively). The two ends of the molecule are separated by a long (76 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The spacer imparts water solubility to QBD-10571 and increases the hydrodynamic volume of the conjugate molecule. The azide group provides the click chemistry functionality, while the 2,3,5,6-tetrafluorophenyl (TFP) ester reacts primary and secondary amines. The single molecular weight and discrete chain length of the spacer simplifies analysis of the product and of its conjugates.
TFP esters are an alternative to the widely popular N-hydroxysuccinimidyl (NHS) esters. TFP esters are more hydrolytically stable than NHS esters, and their optimal reaction pH range (7.5 – 8.0) is somewhat higher than NHS esters (7.0 – 7.5). Moreover, TFP esters in their optimal pH range are more reactive toward free amines than NHS esters.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |