Mfg Part Number
QBD-10594-100
Vector Labs QBD-10594-100 DBCO-dPEG®₂₄-MAL - 100 mg (1/EA)
Quick Overview
DBCO-dPEG₂₄-MAL - 25 mg
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DBCO-dPEG®24-MAL, product number QBD-10594, is a long (90 atoms), single molecular weight, discrete polyethylene glycol (dPEG®) crosslinking reagent. The dibenzylcyclooctyne (DBCO) moiety permits strain promoted azide-alkyne cycloaddition (SPAAC), also known as “”copper free click chemistry.”” The maleimidopropyl (MAL) functional group forms a thiol-ether linkage with sulfhydryl groups. The hydrophilic, non-immunogenic dPEG® spacer in DBCO-dPEG®24-MAL provides the benefits of PEG (increased water solubility, non-immunogenicity) without the analytical headaches of PEG dispersity.
The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) discovered by K. Barry Sharpless and coworkers is one of the best known click chemistry reactions, but its in vivo usability is limited by copper toxicity. Carolyn Bertozzi and coworkers developed SPAAC as a way to avoid copper’s toxic effects on living cells using a highly strained cyclooctyne. Developments since the initial publication show that reagents based on DBCO provide excellent, highly selective reactivity with azides, forming a triazole product.
Maleimide groups are widely popular for their ability to react rapidly with sulfhydryl groups via a Michael addition to form thioether bonds.
Vector Laboratories’ dPEG® products clearly differ from traditional, polymeric polyethylene glycol (PEG). Traditional PEG is a disperse polymer product with a Poisson distribution of chain lengths and molecular weights. The intractable mixture of chain lengths and molecular weights in traditional PEG products creates significant analytical challenges. In contrast, Vector Laboratories’ dPEG® products are single molecular weight compounds with discrete chain lengths. Using Vector Laboratories’ products greatly simplifies analysis of dPEG®-conjugated compounds.
Vector Laboratories’ dPEG® products clearly differ from traditional, polymeric polyethylene glycol (PEG). Traditional PEG is a disperse polymer product with a Poisson distribution of chain lengths and molecular weights. The intractable mixture of chain lengths and molecular weights in traditional PEG products creates significant analytical challenges. In contrast, Vector Laboratories’ dPEG® products are single molecular weight compounds with discrete chain lengths. Using Vector Laboratories’ products greatly simplifies analysis of dPEG®-conjugated compounds.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |