Mfg Part Number
QBD-10807-1000
Vector Labs QBD-10807-1000 Lipoamido-dPEG®₈-acid - 1000 mg (1/EA)
Quick Overview
Lipoamido-dPEG₂₄-acid - 100 mg
$1,389.99
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Lipoamido-dPEG®8-acid, product number QBD-10806, is a single molecular weight, discrete PEG (dPEG®) surface modification reagent for metal surfaces, especially gold and silver. The hydrophilic dPEG®8 spacer is 36 atoms (41.2 Å) long. The lipoamide moiety rapidly forms stable dative bonds with gold or silver. Using a carbodiimide such as EDC and an acylating agent such N-hydroxysuccinimide (NHS), the propionic acid group will react with free amines to form amide bonds. The water-soluble, non-immunogenic dPEG® spacer adds hydrodynamic volume to conjugates made with this product. For circulating nanoparticles, the increased hydrodynamic volume reduces or eliminates opsonization and facilitates a longer circulation time in vivo.
Lipoic acid, also known as thioctic acid and alpha-lipoic acid (ALA), is an organosulfur compound used by cells as an essential cofactor. The sulfur atoms at positions C6 and C8 form a disulfide bond in a five (5)-membered ring. Like other thiol products, lipoic acid readily forms dative bonds with gold, silver, and other metals. Because two dative bonds form for each molecule of lipoic acid, the thiol-metal dative bond is more stable than dative bonds formed with compounds containing one free thiol atom. Lipoic acid exists typically in an oxidized (closed ring) state. It is readily reduced to an open ring state called dihydrolipoic acid (DHLA) using tris(2-carboxyethyl)phosphine (TCEP) or other reducing agents.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |