Mfg Part Number
QBD-11087-1000
Vector Labs QBD-11087-1000 m-dPEG®₁₃-TFP ester - 1000 mg (1/EA)
Quick Overview
MAL-dPEG₂₄-amido-dPEG₂₄-DSPE
$725.88
Order will ship within 1-3 business days
m-dPEG®13-TFP ester, product number QBD-11087, is a medium-length (41 atoms, 47.3 Å), methyl-terminated, discrete-chain-length polyethylene glycol (dPEG®) spacer functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for reaction with free amines. m-dPEG®13-TFP ester is just one member of an comprehensive line of methyl-terminated dPEG® products that includes dPEG® spacers containing 2 to 49 ethylene glycol units.
TFP esters react optimally with free amines at pH 7.5 – 8.0 and are generally more hydrolytically stable in water and aqueous buffers than NHS esters. In aqueous media, the hydrolytic rate of the ester to the carboxylic acid increases with increasing pH. Reacting surface amines on biomolecules (e.g., proteins and peptides) with this uncharged, methyl-capped dPEG® spacer may alter the overall charge of the resulting conjugates.
Many applications could employ m-dPEG®13-TFP ester, including the following:
vaccine development (modifying the immunogenicity of biomolecules);
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.
vaccine development (modifying the immunogenicity of biomolecules);
dendrimer construction;
PK and immunogenicity improvements for dendrimers, peptides, and proteins;
cell surface engineering;
peptide synthesis and modification to improve water solubility or decrease immunogenicity;
coating of nanoparticles, quantum dots, and carbon nanotubes; and
prevention of protein aggregation.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |