Mfg Part Number
QBD-11135-100
Vector Labs QBD-11135-100 Phthalimidooxy-dPEG®₁₂-NHS ester - 100 mg (1/EA)
Quick Overview
Phthalimidooxy-dPEG₁₂-NHS ester
$303.77
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Phthalimidooxy-dPEG®12-NHS ester, product number QBD-10011, is a protected aminooxy compound linked to an amine-reactive N-hydroxysuccinimidyl (NHS) ester through a medium-length (41 atoms, 46.3 Å), single molecular weight, discrete polyethylene glycol (dPEG®) spacer. This allows a hydrophilic, protected aminooxy group to be installed on peptides, proteins, small molecules, and amine-functionalized surfaces.
The phthaloyl moiety on phthalimidooxy-dPEG®4-NHS ester stably protects the aminooxy group. Following amide bond formation, the phthalimide group can be removed using aqueous hydrazine or hydroxylamine, leaving the aminooxy group free to react. Oxime bonds form from the reaction between an aminooxy group and an aldehyde (creating an aldoxime bond) or ketone (creating a ketoxime bond). Compared to hydrazone bonds, oxime bonds are exceptionally stable. They do not break under physiological or even slightly acidic conditions that can occur under some physiological states.
The amine-reactive NHS ester has optimal reactivity in the pH range of 7.0 – 7.4. This group should be reacted first as the subsequent deprotection step for the aminooxy group will also react with the NHS ester.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |