Mfg Part Number
QBD-11160-500
Vector Labs QBD-11160-500 DOTA-tris(acid)-amido-dPEG®₄-TFP ester - 500 mg (1/EA)
Quick Overview
DOTA-tris(acid)-amido-dPEG₁₂-TFP ester - 100 mg
$593.28
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DOTA-tris(acid)-amido-dPEG®4-TFP ester, product number QBD-11160, contains a DOTA-tris(acid) group conjugated to a short (16 atoms, 17.9 Å), discrete polyethylene glycol (dPEG®) spacer and functionalized with 2,3,5,6-tetrafluorophenyl (TFP) ester. The TFP ester reacts specifically and efficiently with amines at an optimal pH range of 7.5 – 8.0. The macrocycle 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a popular, effective bifunctional chelator of trivalent lanthanide and yttrium radioisotopes. It is used in radiopharmacy for imaging, diagnostic, and therapeutic applications.
The short, amphiphilic, flexible dPEG® linker between the DOTA and the TFP ester moieties increases the hydrodynamic volume and water solubility of conjugate molecules. The increased hydrodynamic volume can reduce a conjugate molecule’s renal clearance, thereby increasing serum half-life and reducing the dosage of the conjugate required for efficacy. Moreover, dPEG® is non-immunogenic, and the increased hydrodynamic volume helps reduce the immunogenicity of conjugated molecules.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 500 mg |