Mfg Part Number
QBD-11202-1000
Vector Labs QBD-11202-1000 Bromoacetamido-dPEG®₁₂-TFP ester - 1000 mg (1/EA)
Quick Overview
Bromoacetamido-dPEG₂₄-TFP ester - 100 mg
$908.21
Order will ship within 1-3 business days
Bromoacetamido-dPEG®12-TFP ester, product number QBD-11202, is a medium-length (42 atoms, 48.7 Å), single molecular weight, discrete PEG (dPEG®) crosslinker functionalized with a thiol-reactive bromoacetate group on one end and an amine-reactive 2,3,5,6-tetrafluorophenyl (TFP) ester on the other.
The medium-length, flexible, non-immunogenic dPEG® crosslinker increases the hydrodynamic volumes of conjugates in aqueous media, thereby increasing water solubility. The increased hydrodynamic volume can reduce or eliminate conjugate molecules’ renal clearance and shield conjugates from opsonization.
The bromoacetate moiety is an alternative to the maleimide group, reacting chemoselectively with free thiols at pH ≥8.0. It is useful for situations where the conjugate molecule needs to be kept at a high pH (≥8.0), above the range where maleimides can be used effectively, or in constructs where maleimide groups are unstable.
TFP esters are an alternate reactive group to the N-hydroxysuccinimidyl (NHS) ester and reacts with amines at an optimal pH range of 7.5 – 8.0, higher than the optimal range for NHS esters (pH 7.0 – 7.5). TFP esters are more hydrolytically stable than NHS esters, and they are more reactive toward amines in their optimal pH range than NHS esters are within the pH range 7.0 – 7.5.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 1000 mg |