Mfg Part Number
QBD-11204-100
Vector Labs QBD-11204-100 Bromoacetamido-dPEG®₁₁-azide - 100 mg (1/EA)
Quick Overview
Bromoacetamido-dPEG₁₁-azide
$424.22
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Bromoacetamido-dPEG®11-azide, product number QBD-11204, crosslinks free thiols with click chemistry alkyne partners across a medium-length (39 atoms, 46.0 Å) single molecular weight, discrete PEG (dPEG®) bridge.
The medium-length dPEG® linker is amphiphilic and adds hydrodynamic volume and water solubility to conjugate molecules. The flexible, non-immunogenic spacer can reduce or eliminate renal clearance and help shield conjugates from opsonization through the increased hydrodynamic volume the dPEG® linker imparts.
The bromoacetate moiety reacts chemoselectively with free thiols at pH >8.0. The bromoacetate group is an alternative to the maleimide group and is used in situations where the target molecule needs to be at a high pH. The azide group reacts with a suitable alkyne partner via metal-catalyzed (Cu, Ru) or strain-promoted (copper-free) click chemistry. Moreover, Bromoacetamido-dPEG®11-azide is stable, unlike MAL-PEG-azide constructs, which are somewhat unstable.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |