Mfg Part Number
QBD-11217-100
Vector Labs QBD-11217-100 Bromoacetamido-dPEG®₃-azide - 100 mg (1/EA)
Quick Overview
Bromoacetamido-dPEG₃-azide
$303.77
Order will ship within 1-3 business days
Bromoacetamido-dPEG®3-azide, product number QBD-11217, is discrete PEG (dPEG®) crosslinker that facilitates the crosslinking of free thiols with click chemistry alkyne partners across a short (16 atoms, 17.5 Å) single molecular weight PEG bridge.
The short, amphiphilic dPEG® linker adds hydrodynamic volume to conjugate molecules and increases their water solubility. The flexible, non-immunogenic spacer can reduce or eliminate renal clearance and help shield conjugates from opsonization through the increased hydrodynamic volume the dPEG® linker imparts.
The bromoacetate moiety reacts chemoselectively with free thiols at pH >8.0. It is an alternative to the maleimide group and is used in situations where the target molecule needs to be at a high pH. The azide group reacts with a suitable alkyne partner via metal-catalyzed (Cu, Ru) or strain-promoted (copper-free) click chemistry. Moreover, Bromoacetamido-dPEG®3-azide is stable, unlike MAL-PEG-azide constructs, which are somewhat unstable.
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161700 |
| Reagent Application | Bioconjugation |
| Reagent Size | 100 mg |