Vector Labs QBD-11303-100 MAL-dPEG®₂₄-amido-dPEG®₂₄-TFP ester - 100 mg (1/EA) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

MAL-dPEG®24-amido-dPEG®24-TFP ester, product number QBD-11303, is a monodisperse, crosslinking PEGylation reagent that joins sulfhydryl groups to amines through a long (158 atoms, 183.5 Å), single molecular weight, discrete PEG (dPEG®) chain. One end of the crosslinker is functionalized with a maleimidopropyl (maleimide) group for reaction with free thiols, and the other end has the 2,3,5,6-tetrafluorophenyl (TFP) ester of propionic acid for reaction with free amines. The dPEG® linker consists of two dPEG®24 chains joined by an amide bond, making it functionally a dPEG®48 crosslinker with a molecular weight that is slightly more than 2000 Daltons. At pH 6.5 – 7.5, the maleimide group reacts specifically with sulfhydryl (thiol) groups to form a thioether bond. The TFP ester reacts with free amines to form amide bonds at an optimum reaction pH range of 7.5 – 8.0. Crosslinking free thiols to free amines is one of the most popular and most useful reactions in bioconjugate chemistry. These reactions require heterobifunctional reagents that bridge the two groups. Typical, traditional crosslinkers are short and hydrophobic and frequently trigger aggregation and precipitation of conjugates made from them. In addition, traditional PEG crosslinkers use non-uniform (dispersed) polymer PEGs that consist of an intractable mixture of PEG chain lengths and molecular weights. The complexity arising from non-uniform PEG crosslinkers makes analyzing conjugates a challenging exercise. In contrast, Vector Laboratories’ dPEG® crosslinking products are water-soluble, amphiphilic, single molecular weight PEG compounds with discrete chain lengths. Our dPEG® products are uniform in chain length and molecular weight (Ð = 1). This uniformity of our dPEG® products eliminates one of the most vexing analytical difficulties faced by users of traditional polymer PEG products.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161700
Reagent Application	Bioconjugation
Reagent Size	100 mg

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