Mfg Part Number
Ab00103-16.0
Vector Labs Ab00103-16.0 Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)], Human IgA1, kappa (50 μg)
Quick Overview
A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
$692.90
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| Product Class: | Purified |
|---|---|
| Expected Species Reactivity: | Human |
| Clone ID: | 4D5-8 (trastuzumab) |
| Isotype: | IgA1 |
| Synonyms: | CD340; Metastatic lymph node gene 19 protein (MLN 19); Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; p185HER2; EGFR |
| Amount: | 50 μg |
| Application Codes Clone: | ELISA; FC; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder. |
| Application Notes: | This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |