Mfg Part Number
Ab00166-2.0-VXL
Vector Labs Ab00166-2.0-VXL Anti-CD8 alpha/Lyt-2 [YTS 169.4], Mouse IgG2a, kappa (10 mg)
Quick Overview
Murine CD8 (Lyt-2).
$1,394.90
Order will ship within 1-3 business days
| Product Class: | VivopureX |
|---|---|
| Expected Species Reactivity: | Mouse |
| Clone ID: | YTS 169.4 |
| Synonyms: | Leu2; CD8; CD8A; CD8a molecule; CD8a antigen; Leu2 T-lymphocyte antigen; Lyt-2; Lyt2OKT8; p32T-cell antigen Leu2; T-cell antigen; T cell co-receptor; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; T8 T-cell antigen |
| Amount: | 10 mg |
| Application Codes Clone: | FC; IHC; IHC-Fr; depletion; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | IgG2b |
| Storage Temperature: | All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognises the murine CD8 cell surface antigen expressed by a subset of T lymphocytes. |
| Application Notes: | The antibody has been shown to show depleting activity in vivo. Mice have two alleles for CD8, Lyt2.1, and Lyt2.2, which are restricted to certain mouse strains. Lyt2.1, for example, is expressed in the mouse strains CBA, AKR, C3H, and DBA, whereas Lyt2.2 is expressed in the mouse strains BALB/c and C57BL/6 (B/6). YTS 169.4 was originally raised against CBA mouse thymocytes. However, there are publications in which it has been used in C57BL/6 and BALB/c mice, wherein it was used specifically as a pan-reactive Lyt2 reagent (Tavaré et al., 2014; PMID: 24390540). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |