Mfg Part Number
Ab00284-8.4
Vector Labs Ab00284-8.4 Anti-CD28 [JJ316], Rat IgG2b, Fc Silent™, kappa (200 μg)
Quick Overview
Made by immunizing BALB/c mice with rat CD28 cDNA-transfected A20/J cells.
$517.40
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| Product Class: | Purified |
|---|---|
| Expected Species Reactivity: | Rat |
| Clone ID: | JJ316 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | TP44; T-cell-specific surface glycoprotein CD28 |
| Amount: | 200 μg |
| Application Codes Clone: | CoStim; Superagonism; FC; IF; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a chimeric antibody, created to reduce immunogenicity during in vivo applications, that does not bind complement or Fc-receptors. |
| Specificity Statement: | Recognises rat CD28 and can trigger T-cell proliferation in vitro and in vivo. |
| Application Notes: | This antibody binds rat CD28 and can convey as a co-stimulatory signal. At 100-1000-fold higher concentration than required for co-stimulation JJ316 (unlike the clone JJ319 marketed by competitors (see Tacke et al. 1997)) can induce proliferation of all T-cell subsets without TCR engagement. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |