Mfg Part Number
Ab00285-1.6
Vector Labs Ab00285-1.6 Anti-CD28 [D665], Mouse Fab fragment, His-Tagged, kappa (200 μg)
Quick Overview
The original D665 antibody was generated by immunizing mice alternately with A20 cells expressing mCD28 i.p. and with recombinant mCD28Ig s.c.
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| Product Class: | Purified |
|---|---|
| Expected Species Reactivity: | Mouse |
| Clone ID: | D665 |
| Heavy Chain Modification: | His-Tagged |
| Synonyms: | TP44; T-cell-specific surface glycoprotein CD28; TP44 |
| Amount: | 200 μg |
| Application Codes Clone: | CoStim; Superagonism; FC; SPR; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds to the laterally exposed C′D loop of CD28 and induces T cell proliferation without TCR ligation. |
| Application Notes: | This antibody binds to mouse CD28. The original mouse IgG1 version was shown to trigger T-cell proliferation in vitro and in vivo in a TCR-independent manner and is a superagonistic antibody. This antibody does not compete with E18 (Ab00286). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |