Mfg Part Number
Ab00296-25.0
Vector Labs Ab00296-25.0 Anti-C5 [Eculizumab], Human IgG2/4, kappa (200 μg)
Quick Overview
C5 is activated by C5 converatse into C5a, an anaphylatoxin, and C5b a component of the membrane attack complex.
$517.40
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| Product Class: | Purified |
|---|---|
| Expected Species Reactivity: | Human |
| Clone ID: | Eculizumab |
| Synonyms: | Complement Component 5; CPAMD4; Complement protein C5; h5G1.1 |
| Amount: | 200 μg |
| Application Codes Clone: | Block; EM; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2/4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. |
| Specificity Statement: | Binds human C5 centred in the MG7 domain, at an epitope spanning Lys-879 to Arg-885 (Jore et al. 2016) Polymorphisms at Arg-885 correlate with drug resistance. Eculizumab demonstrates no appreciable species cross-reactivity. It is highly species specific. with no appreciable activity against chimpanzee, baboon, rhesus or cynomologous monkey, pig, rabbit, guinea pig, or rat complement |
| Application Notes: | This antibody inhibits activation of C5. The human Fab version (Ab00296-10.6) of this antibody was used by Jore et al. (2016, PMID: 27018802) to determine the binding site of this antibody to C5. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |