Mfg Part Number
Ab00354-10.7
Vector Labs Ab00354-10.7 Anti-CNPS [3E5], Human F(ab)2, AbFab2™ His-Tagged, kappa (200 μg)
Quick Overview
A covalent serotype A Glucuronoxylomannan (GXM) -tetanus toxoid conjugate (GXM-TT).
$595.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 3E5 |
| Heavy Chain Modification: | AbFab2™ His-Tagged |
| Synonyms: | CNPS; Cryptococcus neoformans capsular polysaccharide; glucuronoxylomannan |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 23911417 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG3 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original mouse IgG3 format for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | Specifically binds to CNPS. |
| Application Notes: | This antibody binds to Glucuronoxylomannan (GXM), which is the main constituent of the C. neoformans capsule and modulates the inflammatory response of monocytes. In a later study conducted by Yuan et al. 1998 (PMID: 9488395), it was shown that switching the original murine IgG3 antibody to other IgG subtypes, in particular IgG2A, significantly prolonged animal survival in an infection model. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |