Mfg Part Number
Ab00389-1.4
Vector Labs Ab00389-1.4 Anti-Quadruplex DNA [1H6], Mouse IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
Oxy-2 or d(TTTTGGGG)2.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 1H6 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | G4 DNA |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IHC; IF |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2b |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to quadruplex DNA with a Kd of 0.33 nM. Binds to both types of quadruplex DNA, Oxy-2 (d(TTTTGGGG)2) and Ver-3 (d(TGGGGG(TTAGGG)2T). |
| Application Notes: | This antibody binds to quadruplex DNA, which is generated through the association of four guanines bound through Hoogsteen base pairing. G4-forming sequences are associated with immunoglobulin switch regions, promoter sequences, rDNA and telomeric repeats. Ab00389-1.1 was used by Hansel-Hertsch et al. 2016 (PMID: 27618450) in immunofluorescence staining (in comparison to the BG4 anti-G quadruplex antibody, c.f. Ab00174). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |