Mfg Part Number
Ab00400-10.7
Vector Labs Ab00400-10.7 Anti-Angiogenin [26-2F], Human F(ab)2, AbFab2™ His-Tagged, kappa (100 μg)
Quick Overview
Human angiogenin.
$692.90
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| Product Class: | Purified |
|---|---|
| Clone ID: | 26-2F |
| Heavy Chain Modification: | AbFab2™ His-Tagged |
| Synonyms: | ANG; Ribonuclease 5; RNase 5; ALS9; HEL168; RAA1 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; Block; ICC; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | Binds to human angiogenin with a Kd of 1.6 nM. Minimal epitope is W89 and fragment 38-41 (PCKD). |
| Application Notes: | The antibody binds specifically to angiogenin, a member of of the ribonuclease superfamily of proteins, which interacts with actin on the surface of endothelial and smooth muscle cells, inducing neovascularization. Due to its angiogenic activity, angiogenesis plays a key role in the growth and invasiveness of tumour cells, and therefore neutralising monoclonal antibodies such as 26-2F are important anticancer drugs. The monoclonal antibody 26-2F is not directly cytotoxic to tumour cells in vitro, however has been shown to have antagonistic effects in human breast cancer xenografts in athymic mice. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |