Mfg Part Number
Ab00420-1.1
Vector Labs Ab00420-1.1 Anti-CD11c [N418], Mouse IgG1, kappa (200 μg)
Quick Overview
Hamster spleen cells that had been primed to mouse spleen dendritic cells
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | N418 |
| Synonyms: | Integrin alpha-X |
| Amount: | 200 μg |
| Application Codes Clone: | FACS; FC; IF; in vivo |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Hamster IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to mouse and human CD11c. |
| Application Notes: | This antibody binds to human CD11, which is part of the human integrin receptor for fibrinogen, recognizing a GPR motif. The receptor is involved in cell-cell contacts, chemotaxis, and inflammatory responses. The binding of this antibody to its target was originally evaluated via FACS (Metlay et al., 1990; PMID: 2185332). This antibody was used for FC (Liu et al., 1998; PMID: 9723687). This antibody was used in vivo as a tool to target the delivery of a model antigen specifically to dendritic cells in mice, resulting in rapid and high antibody response (Wang et al., 2000; PMID: 10639168). Conjugating this antibody to synthetic peptides enhanced their immunogenicity (Berry et al., 2003; PMID: 10639168). This antibody was successfully used in an IF assay (AbAb internal results). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |