Mfg Part Number
Ab00424-201.4
Vector Labs Ab00424-201.4 Anti-Glucose-dependent insulinotropic Receptor [Gipg013], Dog IgG2 (IgG-B), Fc Silent™, lambda (200 μg)
Quick Overview
Human GIPr.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | Gipg013 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | GIPr |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; Blocking; IF |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric dog antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr. |
| Application Notes: | This antibody binds to GIPr, a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81%. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |